Studies on Streptomycin

Counter-current distribution studies on streptomycin; the tautomerism of streptomycin.

The simplicity and reproducibility which characterize the conversion of streptomycin to malt01 (1) by heating in dilute alkali have made this reaction the basis of a frequently used analytical method for streptomycin (2). When used in these laboratories as a method of assaying streptomycin preparations, however, the malt01 reaction consistently gave lower yields per unit of potency with pure st...

Enzymic Studies on the Biosynthesis of Streptomycin

1; Heat extracts of mature mycelia of streptomycin-producing strains of Sfreptomyces contain two compounds which, when incubated with arginine-guanidino-‘*C plus a crude enzyme preparation from S. griseus ATCC 12475 containing a&nine: X amidinotrausferase, give products detected as radioactive Peaks I and II. Heat extracts from S. bluensis var. bluensis, which synthesizes bluensomycin, a monogu...

STUDIES ON STREPTOMYCIN VI. : The Effect of Streptomycin on the Metabolism of Multiplying Bacteria.

In a previous study the authors (Henry et al., 1948) reported on some of the effects of streptomycin (SM) on the metabolism of resting cells of Staphylococcus aureus, BaciUus cereus, and Shigella sonnei. It was found that SM inhibited the oxidation of certain carbohydrates and carbohydrate intermediates by susceptible strains of these organisms, but had no inhibitory effect on resistant strains...

Neuropathological studies on tuberculous meningitis treated with streptomycin.

Studies on sensitivity to streptomycin of the atypical pneumonia agent.

An agent from cases of primary atypical pneumonia associated with development of cold agglutinins (Eaton et al., 1944, 1945) has again been found in recent small outbreaks of this disease (Liu et al., 1955). By using the Coons technique with fluorescein labeled antibody, the site of infection was detected in the lungs of chick embryos following passage by the amniotic route. Previous reports ha...